By Peter I. Bogucki, Pam J. Crabtree
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Additional resources for Ancient Europe, 8000 B.C. to A.D. 1000: An Encyclopedia of the Barbarian World
A diagnostic test needs to have been validated. The validation process quantifies the performance of the test, the possible errors, and the likelihood of their occurrence. Additionally, it gives criteria of reliability, reproducibility, and relevance. DISCOVERY, DEVELOPMENT, AND DEPLOYMENT OF DIAGNOSTICS Methods for discovering diagnostics exploit the information generated through research in physical genomics for many animals and their pathogens.  The conceptual framework for development of the diagnostics incorporates epidemiological considerations.
2] Metronidazole interferes with DNA replication and is particularly useful against anaerobic bacteria and protozoa.  Oxazolidinones such as Zyvox inhibit protein synthesis by binding to the 50S ribosomal subunit. Resistance to oxazolidinones is mediated by mutations to the 23S ribosomal RNA. Fluoroquinolones DEVELOPMENT AND TRANSFER OF ANTIBIOTIC RESISTANCE Antibiotics such as ciprofloxacin and norfloxacin inhibit bacterial topoisomerases and DNA gyrase, thus affecting DNA replication and partitioning.
DNA carrying the gene(s) can be acquired from other microbes by: 1) conjugation, direct cell-to-cell transfer of DNA through a membrane protein complex; 2) transduction with a bacteriophage; and 3) transformation, the uptake of naked DNA from the environment. Conjugative DNA elements that carry antibiotic resistance genes include plasmids and conjugative transposons. These genetic elements can carry more than one antibiotic resistance gene, contributing to multidrug resistance. In animal agriculture, these plasmids containing multiple antibiotic resistance genes are often seen in E.
Ancient Europe, 8000 B.C. to A.D. 1000: An Encyclopedia of the Barbarian World by Peter I. Bogucki, Pam J. Crabtree